TY - JOUR T1 - METABOLISM OF DIGOXIN: ROLE OF THE LIVER IN TRITIATED DIGOXIN DEGRADATION JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 463 LP - 468 VL - 150 IS - 3 AU - Ronald M. Abel AU - Robert J. Luchi AU - Gerald W. Peskin AU - Hadley L. Conn, Jr. AU - Leonard D. Miller Y1 - 1965/12/01 UR - http://jpet.aspetjournals.org/content/150/3/463.abstract N2 - The effect of circulatory bypass of the liver on the metabolism of tritiated digoxin was determined in seven dogs. Thin-layer chromatographic techniques were used in the separation of digoxin from its metabolites. Although the metabolism of digoxin was retarded following liver bypass, significant extrahepatic metabolism was observed under both control and bypass conditions. The Williams & Wilkins Comapny ER -