RT Journal Article SR Electronic T1 RETICULOENDOTHELIAL CELLS AS THE SITE OF SULFANILAMIDE ACETYLATION IN THE RABBIT JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 305 OP 308 VO 150 IS 2 A1 William C. Govier YR 1965 UL http://jpet.aspetjournals.org/content/150/2/305.abstract AB The site of acetylation of sulfanilamide and p-aminobenzoic acid in the rabbit has been examined utilizing isolated, intact hepatic parenchymal and reticuloendothelial cells and various other tissues. The acetylation of these compounds, usually attributed to the liver, was found to occur in cells of the reticuloendothelial system. No acetylation could be demonstrated in the hepatic parenchymal cells. Lung and spleen, organs known to contain a high percentage of reticuloendothelial cells, were also found to acetylate these compounds. These findings emphasize the point that data obtained from experiments utilizing whole liver homogenates may not necessarily reflect a function of the hepatic parenchymal cells. The Williams & Wilkins Comapny