PT  - JOURNAL ARTICLE
AU  - Govier, William C.
TI  - RETICULOENDOTHELIAL CELLS AS THE SITE OF SULFANILAMIDE ACETYLATION IN THE RABBIT
DP  - 1965 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 305--308
VI  - 150
IP  - 2
4099  - http://jpet.aspetjournals.org/content/150/2/305.short
4100  - http://jpet.aspetjournals.org/content/150/2/305.full
SO  - J Pharmacol Exp Ther1965 Nov 01; 150
AB  - The site of acetylation of sulfanilamide and p-aminobenzoic acid in the rabbit has been examined utilizing isolated, intact hepatic parenchymal and reticuloendothelial cells and various other tissues. The acetylation of these compounds, usually attributed to the liver, was found to occur in cells of the reticuloendothelial system. No acetylation could be demonstrated in the hepatic parenchymal cells. Lung and spleen, organs known to contain a high percentage of reticuloendothelial cells, were also found to acetylate these compounds. These findings emphasize the point that data obtained from experiments utilizing whole liver homogenates may not necessarily reflect a function of the hepatic parenchymal cells. The Williams & Wilkins Comapny