RT Journal Article
SR Electronic
T1 THE RELATIVE ANALGESIC AND RESPIRATORY EFFECTS OF PHENAZOCINE AND MORPHINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 337
OP 345
VO 144
IS 3
A1 Houde, Raymond W.
A1 Wallenstein, Stanley L.
A1 Bellville, J. Weldon
A1 Robers, Ada
A1 Escarraga, Lourdes Aguto
YR 1964
UL http://jpet.aspetjournals.org/content/144/3/337.abstract
AB A double-blind crossover evaluation of the relative analgesic potency of phenazocine to morphine was carried out-in a series of sequential studies in cancer patients with chronic pain. In terms of peak action, phenazocine was found to be 4.3 times as potent as morphine. In terms of total effects, the relative potency estimate was 3.2. Few volunteered or readily apparent side-effects were observed and those after phenazocine were similar to those after morphine in equianalgesic doses. In a parallel crossover controlled experiment, the relative potency of phenazocine compared to morphine in terms of respiratory effects has been determined in nine healthy subjects. ϕ, the relative potency, was calculated to be 6.28. Based on these results phenazocine appears to produce as much or more respiratory depression as does a conmparable analgesic dose of morphine. The Williams & Wilkins Company