RT Journal Article
SR Electronic
T1 STUDIES ON THE ENZYMATIC N-AND O-DEMETHYLATION OF NARCOTIC ANALGESICS AND EVIDENCE FOR THE FORMATION OF CODEINE FROM MORPHINE IN RATS AND DOGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 265
OP 275
VO 144
IS 2
A1 Christian Elison
A1 Henry W. Elliott
YR 1964
UL http://jpet.aspetjournals.org/content/144/2/265.abstract
AB Graphical analysis of the kinetics of demethylations of codeine and dextromethorphan suggests that there exist in the rat liver different enzymes which are involved in the N- and O-demethylations of these drugs. Experimental evidence is presented for the formation of codeine from morphine in vito and in vitro. The Williams & Wilkins Company