TY - JOUR T1 - POSSIBLE SITES OF ACTION OF THE RESPIRATORY STIMULANT EFFECT OF DOXAPRAM HYDROCHLORIDE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 260 LP - 264 VL - 144 IS - 2 AU - Hitoshi Kato AU - Joseph P. Buckley Y1 - 1964/05/01 UR - http://jpet.aspetjournals.org/content/144/2/260.abstract N2 - Doxapram hydrochloride, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate, has been shown to be a potent respiratory stimulant acting mainly through direct stimulation of central respiratory centers. Data have been presented which indicate that the compound produces a mild stimulation of carotid chemoreceptors. The compound also produces a peripheral stimulating effect due to stimulation of the aortic chemoreceptors and possibly other peripheral chemoreceptors. Doxapram also produced pressor responses through both central and peripheral mechanisms. The Williams & Wilkins Company ER -