RT Journal Article
SR Electronic
T1 HEPATIC ELECTROLYTE AND GLUCOSE RESPONSES TO EPINEPHRINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 61
OP 66
VO 150
IS 1
A1 Fredric S. Elliott
A1 Fred M. Levin
A1 William C. Shoemaker
YR 1965
UL http://jpet.aspetjournals.org/content/150/1/61.abstract
AB The effect of epinephrine was studied in the rabbit liver perfused in situ under normothermic and hypothermic conditions. After 2 µg of epinephrine, perfusion flow rate increased within the first 20 seconds in normothermia; this flow response was delayed in hypothermia. The K concentration of the perfusate leaving the liver and the net rate of hepatic K output increased in response to epinephrine. These maxima were reached 30 seconds after 2 µg of epinephrine administration in both normothermia and hypothermia; with 20 µg of epinephrine the K response was more prolonged. The return of K to control levels was delayed in hypothermic experiments. Chloride concentration of the perfusate increased after epinephrine in the hypothermic liver. Administration of epinephrine in 20-µg doses produced an increase in perfusate pH, HCO3 and total CO2, concentrations; this may indicate either increased HCO3- output or increased CO2 output together with uptake of H ion (or its equivalent), or both. The rate of hepatic glucose output reached maximal values in an average of 3 minutes after epinephrine in normothermia, but was somewhat delayed in hypothermia. The Williams & Wilkins Comapny