RT Journal Article
SR Electronic
T1 THE EFFECT OF EPINEPHRINE ON INTRACELLULAR ACID-BASE METABOLISM OF RAT SKELETAL MUSCLE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 57
OP 60
VO 150
IS 1
A1 Bailey, L. E.
A1 Withrow, C. D.
YR 1965
UL http://jpet.aspetjournals.org/content/150/1/57.abstract
AB The effect of epinephrine on rat skeletal muscle intracellular acid-base metabolism was studied by two independent methods of determining cell pH. A 30-minute i.v. infusion of epinephrine (2 µg/kg/min) was sufficient to cause a substantial extracellular metabolic acidosis, although this dose level had no effect on muscle intracellular acid-base parameters. No ready explanation for these observations is available at present. It thus appears that epinephrine cannot produce its other effects on skeletal muscle by a mechanism affecting either intracellular pH or bicarbonate concentration. The Williams & Wilkins Comapny