TY - JOUR T1 - THE EFFECT OF EPINEPHRINE ON INTRACELLULAR ACID-BASE METABOLISM OF RAT SKELETAL MUSCLE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 57 LP - 60 VL - 150 IS - 1 AU - L. E. Bailey AU - C. D. Withrow Y1 - 1965/10/01 UR - http://jpet.aspetjournals.org/content/150/1/57.abstract N2 - The effect of epinephrine on rat skeletal muscle intracellular acid-base metabolism was studied by two independent methods of determining cell pH. A 30-minute i.v. infusion of epinephrine (2 µg/kg/min) was sufficient to cause a substantial extracellular metabolic acidosis, although this dose level had no effect on muscle intracellular acid-base parameters. No ready explanation for these observations is available at present. It thus appears that epinephrine cannot produce its other effects on skeletal muscle by a mechanism affecting either intracellular pH or bicarbonate concentration. The Williams & Wilkins Comapny ER -