PT  - JOURNAL ARTICLE
AU  - M. K. Coleman
AU  - W. C. Holland
TI  - VASOPRESSOR ACTIVITY OF CYCLOALKANE CARBONYLCHOLINES
DP  - 1964 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 214--217
VI  - 144
IP  - 2
4099  - http://jpet.aspetjournals.org/content/144/2/214.short
4100  - http://jpet.aspetjournals.org/content/144/2/214.full
SO  - J Pharmacol Exp Ther1964 May 01; 144
AB  - The vasopressor effects of several cycloalkane carbonylcholines have been examined in the dog. The order of activity was as follows: cyclopropane carbonylcholine > cyclobutane carbonylcholine > cyclopentane carbonylcholine > cyclohexane carbonylcholine. The pressor activity of these substances was compared with that of the corresponding saturated and unsaturated alkyl acid esters of choline. It would appear from the analysis that the cyclopropyl and cyclobutyl ring systems are equivalent to a double bond in the β,β position in the acyl side chain of aliphatic acid esters of choline. Physical evidence in favor of this view is discussed. These findings lend further support to the thesis that the formal negative charge density on the carbonyl oxygen is one important factor determining the intensity of the pressor activity of cholinesters. The Williams & Wilkins Company