PT  - JOURNAL ARTICLE
AU  - Hsueh-Hwa Wang
AU  - Tatsuya Kanai
AU  - Shirley Markee
AU  - S. C. Wang
TI  - EFFECTS OF RESERPINE AND CHLORPROMAZINE ON THE VASOMOTOR CENTER IN THE MEDULLA OBLONGATA OF THE DOG
DP  - 1964 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 186--195
VI  - 144
IP  - 2
4099  - http://jpet.aspetjournals.org/content/144/2/186.short
4100  - http://jpet.aspetjournals.org/content/144/2/186.full
SO  - J Pharmacol Exp Ther1964 May 01; 144
AB  - The effect of reserpine and chlorpromazine on the medullary vasomotor mechanism was studied in cross-circulation experiments in dogs anesthetized with morphine-chloralose. The head of the recipient dog was completely isolated from its body except for the spinal cord and sometimes also the vagi, and was perfused by a donor dog. The presser response to electrical stimulation of the medullary vasomotor area was not modified or slightly exaggerated in 14 of 18 experiments when reserpine, 0.2 to 4 mg/kg, was given to the head circulation via the donor animal. In 17 of 20 experiments, this response was depressed by chlorpromazine, 0.1 to 2 mg/kg, similarly administered. It can be concluded that the hypotensive action of chlorpromazine, but not that of reserpine, may be partially explained by a depression of the medullary vasomotor mechanism. The Williams & Wilkins Company