TY - JOUR T1 - INHIBITION OF LIPID MOBILIZATION BY N-ISOPROPYL METHOXAMINE (B.W. 61-43) JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 172 LP - 180 VL - 144 IS - 2 AU - R. A. Salvador AU - K. I. Colville AU - S. A. April AU - J. J. Burns Y1 - 1964/05/01 UR - http://jpet.aspetjournals.org/content/144/2/172.abstract N2 - Administration of N-isopropyl methoxamine (IMA) lowered markedly the fasting plasma free fatty acids (FFA) of the conscious dog and man. Comparative experiments with the D- and L- isomers of the drug showed that this activity resides in the L- form. IMA blocked the marked elevation of plasma FFA and triglycerides which occurs in the dog exposed to a cold environment. The cold-induced rise of circulating FFA was blocked with difficulty in the rat presumably because this species metabolizes the drug at a much more rapid rate than the dog. Man and dog metabolize IMA at about the same rate with a biological half-life of about 6 hours. Since IMA has been shown to exert a potent effect in blocking the catecholamine-induced release of FFA, the results presented here provide additional evidence for the requirement of the sympathetic nervous system in the mobilization of FFA. The Williams & Wilkins Company ER -