TY - JOUR T1 - BLOCKADE OF SOME METABOLIC EFFECTS OF CATECHOLAMINES BY N-ISOPROPYL METHOXAMINE (B.W. 61-43) JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 163 LP - 171 VL - 144 IS - 2 AU - J. J. Burns AU - K. I. Colville AU - L. A. Lindsay AU - R. A. Salvador Y1 - 1964/05/01 UR - http://jpet.aspetjournals.org/content/144/2/163.abstract N2 - N-Isopropyl methoxamine (IMA) blocks certain metabolic effects of catecholamines in the conscious dog. These include the marked rise in plasma free fatty acids (FFA), blood glucose and blood lactic acid induced by epinephrine and the rise in plasma FFA caused by norepinephrine. Also, IMA inhibits in vitro the catecholamine-induced release of FFA from the rat epididymal fat body and the reactivation of rabbit liver phosphorylase. In vivo and in vitro experiments show that the L-isomer is the active form of the drug in exerting these blocking effects. Like IMA, methoxamine blocks in the conscious dog the rise in plasma FFA, the hyperglycemia caused by epinephrine, and the epinephrine-induced release of FFA from the rat epididymal fat body. The Williams & Wilkins Company ER -