PT - JOURNAL ARTICLE AU - Jerome H. Jaffe AU - Seth K. Sharpless TI - THE RAPID DEVELOPMENT OF PHYSICAL DEPENDENCE ON BARBITURATES DP - 1965 Oct 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 140--145 VI - 150 IP - 1 4099 - http://jpet.aspetjournals.org/content/150/1/140.short 4100 - http://jpet.aspetjournals.org/content/150/1/140.full SO - J Pharmacol Exp Ther1965 Oct 01; 150 AB - Thresholds for pentylenetetrazol-induced seizures were determined in cats after varying periods of deep barbiturate intoxication. Thresholds measured 18 to 22 hours after the last dose of barbiturate were significantly decreased even with the shortest period of barbiturate intoxication employed (26 hr). This decrease was interpreted as a manifestation of barbiturate withdrawal. Spontaneous seizures were seen during the withdrawal period after as little as 2 weeks of intoxication. The time course of the development of physical dependence was compared to the time course of the development of denervation supersensitivity in peripheral structures. The Williams & Wilkins Comapny