RT Journal Article
SR Electronic
T1 THE CHRONOTROPIC ACTION OF TYRAMINE STUDIED BY DIRECT PERFUSION OF THE SINUS NODE THROUGH ITS ARTERY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 83
OP 88
VO 144
IS 1
A1 Thomas N. James
A1 Reginald A. Nadeau
YR 1964
UL http://jpet.aspetjournals.org/content/144/1/83.abstract
AB Tyramine injected into the sinus node artery produces more tachycardia (both in peak level and duration) in normal than in reserpinized dogs. The duration of sinus tachycardia from tyramine is much longer than that from norepinephnine administered in the same manner. The responsiveness to tyramine by the sinus node of reserpinized dogs can be transiently restored to normal with norepinephrine, hut not by isoproterenol. Norepinephrine injected into the sinus node artery of reserpinized dogs does not restore the accelerative response to stimulation of the stellate ganglion. The Williams & Wilkins Company