PT  - JOURNAL ARTICLE
AU  - E. W. Maynert
TI  - THE ALCOHOLIC METABOLITES OF PENTOBARBITAL AND AMOBARBITAL IN MAN
DP  - 1965 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 118--121
VI  - 150
IP  - 1
4099  - http://jpet.aspetjournals.org/content/150/1/118.short
4100  - http://jpet.aspetjournals.org/content/150/1/118.full
SO  - J Pharmacol Exp Ther1965 Oct 01; 150
AB  - In normal human subjects the metabolites of 100- to 500-mg doses of N15-labeled pentobarbital or amobarbital were gradually eliminated in the urine over the course of 5 days. Isotope dilution experiments revealed that 51 to 73% of the N15 excreted after a 500-mg dose of amobarbital could be accounted for as 5-ethyl-5-(3-hydroxy-3-methyl) barbituric acid. The dextrorotatory and levorotatory diastereoisomers of 5-ethyl-5-(3-hydroxy-1-methyl butyl)barbituric acid accounted for 7 to 8% and 40 to 43%, respectively, of the urinary isotope derived from a 500-mg dose of pentobarbital. The Williams & Wilkins Comapny