TY - JOUR T1 - METABOLIC FATE OF BENZYL N-BENZYL CARBETHOXYHYDROXAMATE (W-398) JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 105 LP - 108 VL - 150 IS - 1 AU - J. F. Douglas Y1 - 1965/10/01 UR - http://jpet.aspetjournals.org/content/150/1/105.abstract N2 - The metabolic fate of benzyl N-benzyl carebthoxyhydroxamate, W-398, was investigated in the rat and rabbit Utilizing W-398 tagged separately in several positions with C14. In the rat the carbonyl carbon is converted to respiratory carbon dioxide while the benzyl groups are oxidized to benzoic acid. Most of the latter is conjugated with glycine and excreted in the urine as hippuric acid and a small amount is excreted as unchanged benzoic acid. No unchanged W-398 could be detected in the urine of drug-fed rats. The rabbit also metabolizes W-398 to benzoic acid which is excreted partly unchanged and partly as hippuric acid. Two additional metabolites were present in the urine of rabbits receiving labeled W-398. The Williams & Wilkins Comapny ER -