RT Journal Article
SR Electronic
T1 THE EFFECTS OF RESERPINE, GUANETHIDINE AND OTHER AUTONOMIC DRUGS ON FREE FATTY ACID MOBILIZATION INDUCED BY PHENTOLAMINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 57
OP 64
VO 149
IS 1
A1 C. R. Boshart
A1 L. Will
A1 A. Pirré
A1 I. Ringler
YR 1965
UL http://jpet.aspetjournals.org/content/149/1/57.abstract
AB The hypothesis that peripheral catecholamines mediated the rises in free fatty acids resulting from phentolamine administration was investigated. Reserpine and guanethidine pretreatment of dogs or rats and, in addition, ergotamine in rats completely antagonized the increase in free fatty acids induced by phentolamine. Meprobamate, chlorisondamine, hexamethonium, iproniazid, bretylium, Dibenamine and dichloroisoproterenol were not capable of blocking the free fatty acid response under the conditions studied. In dogs both guanethidine and reserpine increased free fatty acid levels in blood when administered alone. Blood glucose levels in dogs declined following guanethidine; reserpine produced an equivocal rise. The transient hyperglycemic and more prolonged hypoglycemic effects of phentolamine in dogs were not altered appreciably by pretreatment with reserpine or guanethidine. The results strongly suggest that peripheral catecholamines play a major role in mediating the effects of phentolamine in fat metabolism. The Williams & Wilkins Comapny