RT Journal Article
SR Electronic
T1 EFFECTS OF THIOPENTAL AND A TETRAHYDROCANNABINOL DERIVATIVE ON AROUSAL AND RECRUITING IN THE CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 138
OP 145
VO 149
IS 1
A1 Boyd, E. S.
A1 Meritt, D. A.
YR 1965
UL http://jpet.aspetjournals.org/content/149/1/138.abstract
AB Thiopental, 2 mg/kg, and DMHP, 0.2 mg/kg, increased the threshold for EEG arousal in acute preparations, and for behavioral, as well as EEG, arousal in chronic preparations. Arousal was induced in all preparations by electrical stimulation of the reticular formation. It is suggested that some responses following thiopental, such as cortical desynchronization from the drug and synchrony instead of asynchrony during stimulation, as well as occasional initial lowering of threshold for arousal by both thiopental and DMHP, may be explained on the basis of an ascending inhibitory reticular system. An attempt to produce EEG and behavioral arousal by the selective circulation of thiopental to the pontomedullary region in chronically prepared animals was successful in only 2 of 8 preparations. Thiopental, 5 to 10 mg/kg, and DMHP, 0.2 mg/kg, had no effect on the recruiting response. The Williams & Wilkins Comapny