PT  - JOURNAL ARTICLE
AU  - Winifred G. Nayler
TI  - THE INOTROPIC ACTION OF <em>d</em>-ALDOSTERONE ON PAPILLARY MUSCLES ISOLATED FROM MONKEYS
DP  - 1965 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 215--217
VI  - 148
IP  - 2
4099  - http://jpet.aspetjournals.org/content/148/2/215.short
4100  - http://jpet.aspetjournals.org/content/148/2/215.full
SO  - J Pharmacol Exp Ther1965 May 01; 148
AB  - The inotropic action of d-aldosterone on monkey isolated papillary muscles was investigated. The results obtained show that the immersion of such papillary muscles in Tyrode solution containing 1 x 10-4 to 1 x 10-4 µg/ml d-aldosterone resulted in a sustained positive inotropic response. The augmented contractions were not associated with a changed duration of contraction. The presence of 1 x l0-4 µg/ml d-aldosterone depressed the contractions of other monkey papillary muscle preparations. The positive inotropic action of d-aldosterone was not blocked by prior treatment of the papillary muscles with the, β-adrenergic blocking drug, pronethalol. The Williams & Wilkins Comapny