PT  - JOURNAL ARTICLE
AU  - T. P. Pruss
AU  - G. D. Maengwyn-Davies
AU  - M. Wurzel
TI  - COMPARISON OF EFFECTS OF AROMATIC SYMPATHOMIMETIC AMINES ON RABBIT AORTIC STRIP AND RABBIT BLOOD PRESSURE
DP  - 1965 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 76--85
VI  - 147
IP  - 1
4099  - http://jpet.aspetjournals.org/content/147/1/76.short
4100  - http://jpet.aspetjournals.org/content/147/1/76.full
SO  - J Pharmacol Exp Ther1965 Jan 01; 147
AB  - Sympathomimetic amines of the aryl-alkylamine type were used to contract the isolated rabbit aorta strip. The importance of the functional groups of such molecules for the contractile activity was evaluated. The same amines were used to obtain blood pressure responses in the rabbit. It was found that pressor compounds invariably contracted the isolated aortic strip. Those compounds which did not contract the aortic strip caused only depressor responses. The sequence of relative potency for this arterial smooth muscle contraction and for blood pressure responses is essentially the same. However, some compounds were relatively more effective on the aortic strip than on blood pressure, and vice versa. The Williams & Wilkins Comapny