PT  - JOURNAL ARTICLE
AU  - James R. Fouts
AU  - Larry A. Rogers
TI  - MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYLCHOLANTHRENE IN RATS
DP  - 1965 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 112--119
VI  - 147
IP  - 1
4099  - http://jpet.aspetjournals.org/content/147/1/112.short
4100  - http://jpet.aspetjournals.org/content/147/1/112.full
SO  - J Pharmacol Exp Ther1965 Jan 01; 147
AB  - Hepatic microsomal drug metabolizing enzyme activity and hepatic ultrastructure have been studies in rats treated with phenobarbital, chlordane, benzpyrene, or methylcholanthrene. These studies have allowed a classification of these stimulators of drug metabolism into groups: phenobarbital and chlordane vs. benzpyrene and methylecholanthrene. Phenobarbital and chlordane stimulate a variety of microsomal drug metabolisms and also appear to cause a marked proliferation of smooth-surfaced endoplasmic reticulum (SER) in the hepatic cell. Benzpyrene and methylcholanthrene stimulate only a few microsomal drug metabolizing enzymes and do not appear to cause any pronounced increase in hepatic cell SER. The Williams & Wilkins Comapny