@article {Fouts112, author = {James R. Fouts and Larry A. Rogers}, title = {MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYLCHOLANTHRENE IN RATS}, volume = {147}, number = {1}, pages = {112--119}, year = {1965}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Hepatic microsomal drug metabolizing enzyme activity and hepatic ultrastructure have been studies in rats treated with phenobarbital, chlordane, benzpyrene, or methylcholanthrene. These studies have allowed a classification of these stimulators of drug metabolism into groups: phenobarbital and chlordane vs. benzpyrene and methylecholanthrene. Phenobarbital and chlordane stimulate a variety of microsomal drug metabolisms and also appear to cause a marked proliferation of smooth-surfaced endoplasmic reticulum (SER) in the hepatic cell. Benzpyrene and methylcholanthrene stimulate only a few microsomal drug metabolizing enzymes and do not appear to cause any pronounced increase in hepatic cell SER. The Williams \& Wilkins Comapny}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/147/1/112}, eprint = {https://jpet.aspetjournals.org/content/147/1/112.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }