TY - JOUR T1 - AN ADAPTIVELY STIMULATED O-DEMETHYLATING SYSTEM IN RAT LIVER MICROSOMES AND ITS KINETIC PROPERTIES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 61 LP - 65 VL - 146 IS - 1 AU - K. J. Netter AU - G. Seidel Y1 - 1964/10/01 UR - http://jpet.aspetjournals.org/content/146/1/61.abstract N2 - The microsomal O-demethylation of p- nitroanisole to p-nitrophenol can be stimulated by pretreatment of rats with phenobarbital and other drugs. Normal and induced microsomal O-demethylases have the same overall substrate constants. Inhibition of the stimulated enzyme by the microsome inhibitor SKF 525-A shows the same kinetic characteristics as does the control demethylase, namely noncompetitive inhibition. Available evidence may suggest the identity of original and induced O-demethylase protein. The Williams & Wilkins Comapny ER -