RT Journal Article SR Electronic T1 THE EFFECT OF AN ADRENERGIC BETA-RECEPTOR ANTAGONIST ON THE CARDIOVASCULAR SYSTEM OF THE DOG JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 344 OP 349 VO 143 IS 3 A1 David E. Donald A1 Jay Kvale A1 John T. Shepherd YR 1964 UL http://jpet.aspetjournals.org/content/143/3/344.abstract AB Nethalide (1-[2'-naphthyl]-2-isopropylaminoethanol hydrochloride) was studied in normal and in atropinized dogs under pentobarbital anesthesia and in dogs with chronic cardiac denervation. When given intravenously in a dose of 6 to 7 mg/kg, it increased cardiac output and stroke volume. The heart rate slowed in normal and in atropinized dogs, was unchanged in dogs with cardiac denervation when anesthetized, and quickened when they were conscious. It can block the β-receptors in peripheral vessels and can abolish the effect of stimulation of the cardiac sympathetic nerves. It can block the chronotropic effects of norepinephnine and epinephrine. The Williams & Wilkins Company