PT - JOURNAL ARTICLE AU - David E. Donald AU - Jay Kvale AU - John T. Shepherd TI - THE EFFECT OF AN ADRENERGIC <em>BETA</em>-RECEPTOR ANTAGONIST ON THE CARDIOVASCULAR SYSTEM OF THE DOG DP - 1964 Mar 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 344--349 VI - 143 IP - 3 4099 - http://jpet.aspetjournals.org/content/143/3/344.short 4100 - http://jpet.aspetjournals.org/content/143/3/344.full SO - J Pharmacol Exp Ther1964 Mar 01; 143 AB - Nethalide (1-[2'-naphthyl]-2-isopropylaminoethanol hydrochloride) was studied in normal and in atropinized dogs under pentobarbital anesthesia and in dogs with chronic cardiac denervation. When given intravenously in a dose of 6 to 7 mg/kg, it increased cardiac output and stroke volume. The heart rate slowed in normal and in atropinized dogs, was unchanged in dogs with cardiac denervation when anesthetized, and quickened when they were conscious. It can block the β-receptors in peripheral vessels and can abolish the effect of stimulation of the cardiac sympathetic nerves. It can block the chronotropic effects of norepinephnine and epinephrine. The Williams &amp; Wilkins Company