RT Journal Article SR Electronic T1 BLOCKING OF THE IN VIVO EFFECTS OF BRADYKININ AND KALLIDIN WITH CARBOXYPEPTIDASE B JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 327 OP 334 VO 142 IS 3 A1 Erdös, Ervin G. A1 Wohler, J. Richard A1 Levine, Macy I. YR 1963 UL http://jpet.aspetjournals.org/content/142/3/327.abstract AB Intravenous injection of carboxypeptidase B abolished or very much decreased the hypotension caused by bradykinin, kallidin, 6-glycine bradykinin or kallikrein. The experiments were done on guinea pigs, rabbits or cats. The administration of the enzyme preparation did not block the effects of histamine and eledoisin. Subcutaneous injection of carboxypeptidase B also prevented in part the capillary permeability changes caused by intradermal injection of bradykinin in guinea pigs. The decrease in the circulating enzyme level and return of bradykinin effect in rabbits and cats were correlated. The results were explained by the very rapid in vivo inactivation of those peptides which have a C-terminal arginine. The Williams & Wilkins Company