PT  - JOURNAL ARTICLE
AU  - Erdös, Ervin G.
AU  - Wohler, J. Richard
AU  - Levine, Macy I.
TI  - BLOCKING OF THE <em>IN VIVO</em> EFFECTS OF BRADYKININ AND KALLIDIN WITH CARBOXYPEPTIDASE B
DP  - 1963 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 327--334
VI  - 142
IP  - 3
4099  - http://jpet.aspetjournals.org/content/142/3/327.short
4100  - http://jpet.aspetjournals.org/content/142/3/327.full
SO  - J Pharmacol Exp Ther1963 Dec 01; 142
AB  - Intravenous injection of carboxypeptidase B abolished or very much decreased the hypotension caused by bradykinin, kallidin, 6-glycine bradykinin or kallikrein. The experiments were done on guinea pigs, rabbits or cats. The administration of the enzyme preparation did not block the effects of histamine and eledoisin. Subcutaneous injection of carboxypeptidase B also prevented in part the capillary permeability changes caused by intradermal injection of bradykinin in guinea pigs. The decrease in the circulating enzyme level and return of bradykinin effect in rabbits and cats were correlated. The results were explained by the very rapid in vivo inactivation of those peptides which have a C-terminal arginine. The Williams & Wilkins Company