PT  - JOURNAL ARTICLE
AU  - Zimmerman, Arthur M.
AU  - Harris, Laurence S.
TI  - MICROCIRCULATION: EFFECTS OF GUANETHIDINE AND RESERPINE
DP  - 1963 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 76--82
VI  - 142
IP  - 1
4099  - http://jpet.aspetjournals.org/content/142/1/76.short
4100  - http://jpet.aspetjournals.org/content/142/1/76.full
SO  - J Pharmacol Exp Ther1963 Oct 01; 142
AB  - The effects of two antihypertensive agents, guanethidine and reserpine, were evaluated on the microcirculation by direct microscopic studies of rat mesoappendix vasculature. The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes. Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). The chronic administration of both drugs produced a pattern of sensitization very similar to that of topically applied epinephrine. The increased reactivity of the peripheral vascular bed (rat mesocecum), following treatment with reserpine and guanethidine, is discussed in relation to the effects of reserpine and guanethidine on the heart and other tissues. The Williams & Wilkins Company