RT Journal Article
SR Electronic
T1 EFFECTS OF 2-PAM AND SUCCINYLCHOLINE ON NEUROMUSCULAR TRANSMISSION IN THE FROG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 322
OP 328
VO 138
IS 3
A1 Charles Edwards
A1 Kazuo Ikeda
YR 1962
UL http://jpet.aspetjournals.org/content/138/3/322.abstract
AB In the Mg-blocked frog nerve-muscle preparation, the end-plate potential is increased by 2-PAM, and decreased by succinylcholine (SCh). Acetylcholine release was determined statistically as the average number of quanta released by each nerve impulse, 2-PAM increased the number of quanta released while SCh apparently reduced the number although it may have affected invasion of the nerve terminals. The agents had little or no effect on the sensitivity of the post-junctional membrane to ACh. It is concluded that the agents act presynaptically.