PT  - JOURNAL ARTICLE
AU  - William C. Love
AU  - Lucinda Carr
AU  - James Ashmore
TI  - LIPOLYSIS IN ADIPOSE TISSUE: EFFECTS OF <em>dl</em>-3,4-DICHLOROISOPROTERENOL AND RELATED COMPOUNDS
DP  - 1963 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 287--294
VI  - 140
IP  - 3
4099  - http://jpet.aspetjournals.org/content/140/3/287.short
4100  - http://jpet.aspetjournals.org/content/140/3/287.full
SO  - J Pharmacol Exp Ther1963 Jun 01; 140
AB  - Increased free fatty acid production by rat epididymal adipose tissue exposed to catecholamines ACTH, TSH and glucagon in vitro was inhibited by dl-3,4-dichloroisoproterenol at concentrations greater than 10-4 molar. This phenomenon was independent of glucose and apparently involved inhibition of the activation of lipolysis rather than an increase in re-esterification of free fatty acid. Free fatty acid release by adipose tissue in vitro was increased by the lower concentrations of dl-3,4-dichloroisoproterenol and maximum free fatty acid production was achieved at 10-5 molar. dl - 1 - (2,4 - Dichlorophenyl) - 2 - t -butyl-aminoethanol was similar in action to dl-3,4-dichloroisoproterenol in that at concentrations above 10-4 molar it effectively inhibited free fatty acid release due to catecholamines; however, unlike dl-3,4-dichloroisoproterenol and several other compounds it did not stimulate free fatty acid production in vitro at any concentration studied.