RT Journal Article
SR Electronic
T1 THE ENZYMATIC N-METHYLATION OF SEROTONIN AND OTHER AMINES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 28
OP 33
VO 138
IS 1
A1 Axelrod, Julius
YR 1962
UL http://jpet.aspetjournals.org/content/138/1/28.abstract
AB An enzyme that transfers the methyl group of S-adenosylmethionine to the amino group of serotonin has been described. It has been partially purified and its properties studied. The serotonin methylating enzyme can N-methylate a variety of normally occurring compounds such as dopamine, normetanephrine, metanephrine, epinephrine, tyramine, and octopamine as well as a variety of foreign compounds such as ephedrine, amphetamine, aniline, normorphine, normeperidine and nornicotine. The enzyme is highly localized in the rabbit lung.