PT - JOURNAL ARTICLE AU - Julius Axelrod TI - THE ENZYMATIC N-METHYLATION OF SEROTONIN AND OTHER AMINES DP - 1962 Oct 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 28--33 VI - 138 IP - 1 4099 - http://jpet.aspetjournals.org/content/138/1/28.short 4100 - http://jpet.aspetjournals.org/content/138/1/28.full SO - J Pharmacol Exp Ther1962 Oct 01; 138 AB - An enzyme that transfers the methyl group of S-adenosylmethionine to the amino group of serotonin has been described. It has been partially purified and its properties studied. The serotonin methylating enzyme can N-methylate a variety of normally occurring compounds such as dopamine, normetanephrine, metanephrine, epinephrine, tyramine, and octopamine as well as a variety of foreign compounds such as ephedrine, amphetamine, aniline, normorphine, normeperidine and nornicotine. The enzyme is highly localized in the rabbit lung.