RT Journal Article SR Electronic T1 ON THE METABOLISM OF o-ETHOXYBENZAMIDE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 226 OP 231 VO 136 IS 2 A1 Clarke Davison A1 John Wangler A1 Paul K. Smith YR 1962 UL http://jpet.aspetjournals.org/content/136/2/226.abstract AB The metabolites of o-ethoxybenzamide in plasma and urine have been investigated in human subjects and in rats. The unaltered compound and its deethylated metabolite, salicylamide, have been found in the plasma. No unaltered o-ethoxybenzamide could be detected in the urine but about one-half of the dose could be detected as either the ethereal sulfate (34%) or the glucuronide (15%) of salicylamide. A small amount of the deamidated product, ethoxybenzoic acid, was found in the human but not in the rat. This acid itself was not deethylated in the rat or human, but largely excreted as a conjugate. Ethoxybenzamide yields lower plasma levels than most nonnarcotic analgetics with the exception of salicylamide, and is rapidly excreted. The low plasma concentrations probably reflect a greater penetration into the tissues. In vitro experiments in the rabbit indicate that the deethylation occurs in the liver in a manner similar to other ethers.