RT Journal Article
SR Electronic
T1 BRAIN 5-HYDROXYTRYPTAMINE AND ANTICONVULSANT ACTIVITY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 179
OP 182
VO 136
IS 2
A1 E. G. Anderson
A1 S. D. Markowitz
A1 D. D. Bonnycastle
YR 1962
UL http://jpet.aspetjournals.org/content/136/2/179.abstract
AB The relationship between the rise in brain 5-hydroxytryptamine and anticonvulsant action of diphenylhydantoin has been investigated, and some correlation between the time courses of each was noted. However, comparison of the relative effects of diphenylhydantoin, phenylisopropyl hydrazine and 5-hydroxytryptophan on the maximal extensor reflex in response to electroshock and rise in brain 5-hydroxytryptamine showed a complete lack of correlation.