RT Journal Article
SR Electronic
T1 APNEA, BRADYCARDIA AND HYPOTENSION IN RESPONSE TO SODIUM SALICYLATE IN THE CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 169
OP 173
VO 136
IS 2
A1 R. Rosenstein
A1 H. L. Borison
YR 1962
UL http://jpet.aspetjournals.org/content/136/2/169.abstract
AB Rapid intravenous injection of large doses of sodium salicylate (100 to 200 mg/kg) in the cat produces a vagally mediated reflex response which includes apnea, bradycardia, and hypotension. The primary receptors for both respiratory and cardiovascular portions of the response are located within the pulmonary circuit. Secondary participation in the reflex response of receptors in the systemic circuit is also indicated. A similarity exists between the response produced by hyperosmotic solutions of sodium salicylate and sodium chloride. The osmolarity of the salicylate solution, however, contributes only slightly to its over-all effect.