RT Journal Article
SR Electronic
T1 ATTENUATION /OF CARDIOVASCULAR RESPONSES TO EXERCISE AS A POSSIBLE BASIS FOR EFFECTIVENESS OF MONOAMINE OXIDASE INHIBITORS IN ANGINA PECTORIS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 39
OP 46
VO 137
IS 1
A1 Goldberg, Leon I.
A1 Horwitz, David
A1 Sjoerdsma, Albert
YR 1962
UL http://jpet.aspetjournals.org/content/137/1/39.abstract
AB The effects of exercise on heart rate and blood pressure of three patients with angina pectoris were determined before, during, and after treatment with a potent monoamine oxidase inhibitor, isocarboxazid. The elevated levels of heart rate and blood pressure produced by exercise were significantly reduced in each patient by isocarboxazid therapy. It is postulated that such attenuation of the cardiovascular response to exercise could be responsible for the effectiveness of monoamine oxidase inhibitors in the treatment of angina pectoris in some patients.