RT Journal Article
SR Electronic
T1 THE EFFECT OF EMETINE ON THE OXIDATION OF SUCCINATE BY HEART HOMOGENATES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 107
OP 113
VO 137
IS 1
A1 Harold C. Heim
A1 Harry C. Froede
A1 Virgel G. Erwin
YR 1962
UL http://jpet.aspetjournals.org/content/137/1/107.abstract
AB Emetine produces a marked increase in the rate of oxidation of succinate by myocardial homogenates and mitochondria. This effect is observed with fresh, but not with aged, homogenates and appears to be related to a suppression of oxaloacetate accumulation, possibly through inhibition of malic dehydrogenase. The results bear considerable similarity to those obtained by other investigators who studied the effect of thyroxine on succinate oxidation.