PT  - JOURNAL ARTICLE
AU  - Harold C. Heim
AU  - Harry C. Froede
AU  - Virgel G. Erwin
TI  - THE EFFECT OF EMETINE ON THE OXIDATION OF SUCCINATE BY HEART HOMOGENATES
DP  - 1962 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 107--113
VI  - 137
IP  - 1
4099  - http://jpet.aspetjournals.org/content/137/1/107.short
4100  - http://jpet.aspetjournals.org/content/137/1/107.full
SO  - J Pharmacol Exp Ther1962 Jul 01; 137
AB  - Emetine produces a marked increase in the rate of oxidation of succinate by myocardial homogenates and mitochondria. This effect is observed with fresh, but not with aged, homogenates and appears to be related to a suppression of oxaloacetate accumulation, possibly through inhibition of malic dehydrogenase. The results bear considerable similarity to those obtained by other investigators who studied the effect of thyroxine on succinate oxidation.