RT Journal Article
SR Electronic
T1 TOXICOLOGY OF ACETOXYCYCLOHEXIMIDE AS A FUNCTION OF SEX AND BODY WEIGHT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 400
OP 405
VO 136
IS 3
A1 Arthur J. Pallotta
A1 Margaret G. Kelly
A1 David P. Rall
A1 John W. Ward
YR 1962
UL http://jpet.aspetjournals.org/content/136/3/400.abstract
AB Acetoxycycloheximide, an antibiotic with antitumor activity, was much more toxic to female rats than to males. It was also more toxic to female mice than to males, but no such difference occurred in dogs. Further, the toxicity of this compound for rats of differing age and weight was rendered nearly uniform by expressing dosage on a mg/animal basis. A mg/kg basis introduced, rather than removed, the factor of body weight. It is of interest that two closely related cycloheximide derivatives showed neither a sex-related difference nor a lack of dependence upon body weight. Also, a summary of the general toxicology of this compound was presented.