RT Journal Article
SR Electronic
T1 THE PHARMACOLOGIC RESPONSE TO 8-AMINOTHEOPHYLLINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 261
OP 264
VO 131
IS 2
A1 HENSALA, JOHN C.
A1 BURGISON, RAYMOND M.
A1 KRANTZ, JOHN C.
YR 1961
UL http://jpet.aspetjournals.org/content/131/2/261.abstract
AB When evaluated for blood pressure depressor effect on dogs anesthetized with ether, the sodium salt of 8-aminotheophyffine (8-A-T Na) exhibited a marked response upon intravenous and intraduodenal administration. This effect could not be repeated in experiments on trained, unanesthetized dogs. Pharmacologic studies on the compound suggest a musculotropic action in eliciting the hypotensive response. The diuretic activity of 8-A-T Na was less marked than that of theophyffine. The effect on coronary flow was comparable to that evoked by aminophyffine. Toxicity was minimal as evidenced by growth curve of the rat and acute toxicity experiments. © 1961, by The Williams & Wilkins Company