PT  - JOURNAL ARTICLE
AU  - HENSALA, JOHN C.
AU  - BURGISON, RAYMOND M.
AU  - KRANTZ, JOHN C.
TI  - THE PHARMACOLOGIC RESPONSE TO 8-AMINOTHEOPHYLLINE
DP  - 1961 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 261--264
VI  - 131
IP  - 2
4099  - http://jpet.aspetjournals.org/content/131/2/261.short
4100  - http://jpet.aspetjournals.org/content/131/2/261.full
SO  - J Pharmacol Exp Ther1961 Feb 01; 131
AB  - When evaluated for blood pressure depressor effect on dogs anesthetized with ether, the sodium salt of 8-aminotheophyffine (8-A-T Na) exhibited a marked response upon intravenous and intraduodenal administration. This effect could not be repeated in experiments on trained, unanesthetized dogs. Pharmacologic studies on the compound suggest a musculotropic action in eliciting the hypotensive response. The diuretic activity of 8-A-T Na was less marked than that of theophyffine. The effect on coronary flow was comparable to that evoked by aminophyffine. Toxicity was minimal as evidenced by growth curve of the rat and acute toxicity experiments. © 1961, by The Williams & Wilkins Company