RT Journal Article
SR Electronic
T1 SPECIFIC BLOCKADE OF THE ADRENAL MEDULLA
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 340
OP 345
VO 130
IS 3
A1 Robert W. Gardier
A1 Benedict E. Abreu
A1 Alice B. Richards
A1 Herman C. Herrlich
YR 1960
UL http://jpet.aspetjournals.org/content/130/3/340.abstract
AB N,N-diisopropyl- N'-isoamyl-N'-diethylaminoethylurea (P-286) reverses the pressor response to acetyicholine in the atropinized dog. This reversal is due to selective blockade of the action of acetyicholine in the adrenal medulla. P-286 possesses a transient vasodepressor action per se, has weak ganglionic blocking action, and is not an adrenergic blocking agent.