RT Journal Article
SR Electronic
T1 STUDIES ON VERATRUM ALKALOIDS. XXIX. THE ACTION OF SOME GERMINE ESTERS AND OF VERATRIDINE UPON BLOOD PRESSURE, HEART RATE AND FEMORAL BLOOD FLOW IN THE DOG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 311
OP 320
VO 130
IS 3
A1 J. M. Benforado
A1 W. Flacke
A1 W. Mosimann
A1 C. R. Swaine
YR 1960
UL http://jpet.aspetjournals.org/content/130/3/311.abstract
AB Four esters of germine, differing in the number of ester linkages and the nature of the participating acids, and veratridine have been investigated for their effect upon blood pressure, heart rate, right atrial pressure and blood flow in the perfused hindlimb of the dog. There were no qualitative differences between germerine, neogermitrine, desacetylgermitetrine and veratridine. Germitetrine had a slower onset and a longer duration of action and its maximally obtainable effects were smaller. The variations in potency between the esters were only small; the germine esters as a group were 3 to 5 times more potent than veratridine. All the hypotensive esters investigated caused a vasodilatation in the vascular bed of the femoral artery which was transmitted by nervous pathways. The dilatation was not influenced by atropine and can therefore not be mediated by cholinergic dilator nerves. Its magnitude was not closely related to the magnitude of the accompanying hypotension, and it is likely that the fall in blood pressure induced by these alkaloids is not entirely due to a decrease in peripheral resistance.