TY - JOUR T1 - A SENSITIVE ASSAY OF MONOAMINE OXIDASE ACTIVITY <em>IN VITRO:</em> APPLICATION TO HEART AND SYMPATHETIC GANGLIA JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 7 LP - 10 VL - 135 IS - 1 AU - Walter Lovenberg AU - Robert J. Levine AU - Albert Sjoerdsma Y1 - 1962/01/01 UR - http://jpet.aspetjournals.org/content/135/1/7.abstract N2 - A sensitive method of measuring monoamine oxidase in vitro based on the rate of indoleacetic acid formation from tryptamine is described. The method is particularly suited for studies on organs with low levels of enzyme activity, e.g., dog heart, or on small samples of tissue, such as a sympathetic ganglion. Correlation of the biochemical and pharmacologic effects of MAO inhibitors in such loci will thereby be facilitated. ER -