PT  - JOURNAL ARTICLE
AU  - John Murphy
AU  - Louis Lasagna
AU  - William Casey
TI  - THE EFFECT OF DOSAGE REGIMEN ON THE DIURETIC EFFICACY OF CHLOROTHIAZIDE IN HUMAN SUBJECTS
DP  - 1961 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 286--290
VI  - 134
IP  - 3
4099  - http://jpet.aspetjournals.org/content/134/3/286.short
4100  - http://jpet.aspetjournals.org/content/134/3/286.full
SO  - J Pharmacol Exp Ther1961 Dec 01; 134
AB  - Ten healthy male subjects were subjected to a controlled double blind study to test the hypothesis that the efficacy of chlorothiazide is a function of dosage regimen. The results indicate that spacing of doses is a potent determinant of diuretic effect and that a given amount of chlorothiazide is more effective when split up into smaller doses given intermittently than when administered in a single dose. It is suggested that the question of dosage regimen be given greater attention in the design of trials on diuretic drugs. In two additional experiments the influence of probenecid on the diuretic efficacy of various dosage regimens of chlorothiazide was also studied. The inconsistent results of these latter experiments suggest that the effect of probenecid on chlorothiazide-induced diuresis is a complex one.