RT Journal Article
SR Electronic
T1 THE RENAL EFFECTS OF CHLOROTHIAZIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 281
OP 285
VO 134
IS 3
A1 A. R. Lavender
A1 Theodore N. Pullman
YR 1961
UL http://jpet.aspetjournals.org/content/134/3/281.abstract
AB Chlorothiazide in dilute solution was administered by constant-speed infusion into one renal artery in each of thirteen dogs. In all dogs there occurred an increase in the excretory rates of chloride, sodium and water with a lesser increase in the excretory rate of potassium. In two dogs the response was limited to the kidney being infused. In the remaining dogs, the response was bilateral but greater in the infused than the control kidney. It is concluded that chiorothiazide acts directly at an intrarenal site to exert its excretory effects. Since renal blood flow and glomerular filtration rate did not change, this site must be tubular in origin.