RT Journal Article
SR Electronic
T1 PHARMACOLOGY OF BENZYDROFLUMETHIAZIDE (NATURETIN)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 273
OP 280
VO 134
IS 3
A1 J. J. Piala
A1 J. W. Poutsiaka
A1 B. N. Craver
A1 J. C. Burke
A1 C. I. Smith
YR 1961
UL http://jpet.aspetjournals.org/content/134/3/273.abstract
AB Benzydroflumethiazide (BHFT) was the most potent of 5 benzothiadiazines studied in rats and dogs. In dogs, moreover, BHFT had a lower clearance rate, a longer half-life in plasma, and a longer duration of action than dihydroflumethiazide. In accord with its very low in vitro carbonic anhydrase inhibitory activity, BHFT did not increase the urinary excretion of bicarbonate. Large intravenous doses caused hypotension in dogs but produced no other significant cardiovascular or autonomic effects and no change in glomerular filtration rate. This compound was lethal in mice only at exceptionally large oral or parenteral doses. In dogs, very large doses given over many weeks lowered moderately the potassium concentrations in the serum but did not produce major electrolyte imbalances.