RT Journal Article
SR Electronic
T1 RENAL EXCRETION OF L-TYROSINE AND ITS DERIVATIVES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 257
OP 265
VO 134
IS 3
A1 K. C. Huang
YR 1961
UL http://jpet.aspetjournals.org/content/134/3/257.abstract
AB Studies of the renal excretion of L-tyrosine and eight of its derivatives have shown that the mono-substituted derivatives behave similarly to L-tyrosine, namely they were reabsorbed by the renal tubules. In contrast, the disubstituted derivatives of L-tyrosine were secreted by the tubules. 3,5-Diiodo-L-tyrosine was used to represent the group of disubstituted compounds on the studies with stop flow technique. It was found that the secretion of this compound was localized in the proximal section and could be blocked by the administration of probenecid.