%0 Journal Article %A R. P. MAICKEL %A E. O. WESTERMANN %A B. B. BRODIE %T EFFECTS OF RESERPINE AND COLD-EXPOSURE ON PITTUITARY-ADRENOCORTICAL FUNCTION IN RATS %D 1961 %J Journal of Pharmacology and Experimental Therapeutics %P 167-175 %V 134 %N 2 %X The effects of reserpine and cold-exposure have been compared on various indices of pituitary adrenal stimulation in rats: adrenal ascorbic acid, plasma corticosterone and FFA, and liver TPO. Both reserpineand cold-exposure elicita marked hypersecretion of ACTH. Of a number of Rauwolfia alkaloids, however, only those compounds which lowered brain stores of norepinephrine and serotonin and produced sedation, also evoked ACTH hypersecretion. A large dose of reserpine or a prolonged cold-exposure decreased the content of ACTH in the pituitary to suchan extent that the animals could not respond to an additional pituitary stimulus. © 1961, by The Williams & Wilkins Company %U https://jpet.aspetjournals.org/content/jpet/134/2/167.full.pdf